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Prediction of response to cancer chemotherapy using immunohistochemical staining
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- Kamoshida Shingo
- Department of Medical Biophysics, Kobe University Graduate School of Health Sciences
Bibliographic Information
- Other Title
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- 免疫組織化学染色によるがん化学療法の感受性予測
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Description
<p>Here, we review the utility of immunohistochemical (IHC) staining as a diagnostic assay in cancers. IHC staining for hormone receptors is used to select patients for hormonal therapy in breast cancers. IHC staining and fluorescent in situ hybridization (FISH) are well-established assays for overexpression of human epidermal growth factor receptor 2 (HER2) protein and amplification of the HER2 gene, respectively; positive results indicate that targeted therapy with trastuzumab, the anti-HER2 antibody, is appropriate. Similarly, the anaplastic lymphoma kinase (ALK) inhibitors, crizotinib and alectinib, can treat non-small cell lung cancers with ALK fusion genes, which are found through diagnostic assays that include IHC staining and FISH; and imatinib is effective for KIT-expressing gastrointestinal stromal tumors. IHC confirmation of target protein expression is also necessary before using targeted agents in hematologic malignancies: CD20 for rituximab, CD30 for brentuximab vedotin, and CC chemokine receptor-4 for mogamurizumab. IHC staining for programmed death-ligand 1 is used to identify non-small cell lung cancer patients who can respond to pembrolizumab, which targets programmed death-1. This review also discusses possible prediction of response to cytotoxic agents through IHC staining for solute carrier transporters, and the differences between IHC staining and western blotting.</p>
Journal
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- Electrophoresis Letters
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Electrophoresis Letters 61 (2), 124-127, 2017
Japanese Electrophoresis Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680740141056
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- NII Article ID
- 130006207331
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- ISSN
- 21892636
- 21892628
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- HANDLE
- 20.500.14094/90005225
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed