重金属汚染による健康障害の分子生物学
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- 中島 泉
- 中部大学
書誌事項
- タイトル別名
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- Molecular mechanisms of pathogenesis of diseases caused by heavy metals in polluted air
抄録
Heavy metals, such as mercury (Hg) and arsenite (As), which are released as pollutants into air when coals are burned for producing electricity, may induce the development of several diseases, including cancers, in humans. Possible molecular mechanisms underlying the pathogenesis of diseases caused by heavy metals were analyzed. Exposure of cells to HgCl_2 in vitro was found to induce a striking activation of protein tyrosine kinases (PTKs), such as Lck, c-Src and RET. Two steps of mechanisms of PTK activation were demonstrated. First, cell surface receptors were aggregated due to a redox-linked reaction between receptors and metal ions, which caused production of reactive oxygen species (ROS). Second, the generated ROS induced redox-linked dimerization or polymerization and activation of PTK molecules. The target site for redox-linked dimerization and activation of PTKs was thought to be localized in the MXXCW motif of the kinase domain, which is conserved in 80 among 81 PTKs in a database.
収録刊行物
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- 石炭科学会議発表論文集
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石炭科学会議発表論文集 42 (0), 3-4, 2005
一般社団法人 日本エネルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282680745944704
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- NII論文ID
- 110006857797
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- ISSN
- 24238309
- 24238295
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可