書誌事項
- タイトル別名
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- Mechanisms of Hepatic Apoptosis Induced by D-Galactosamine and its Suppression by Tea-catechin
- D-Galactosamine誘導肝細胞アポトーシスの発生分子機構とTea-catechinによる抑制
- D Galactosamine ユウドウ カン サイボウ アポトーシス ノ ハッセイ ブンシ キコウ ト Tea catechin ニ ヨル ヨクセイ
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抄録
A molecular mechanism of hepatocyte apoptosis induced by D-galactosamine (D-GalN) administration was studied. We discovered two novel procaspase-3 activating enzymes, named "lysoapoptases" , located in lysosomes with different molecular weights of 52kDa and 18kDa. The content of 52kDa lysoapoptase (lysoapoptase-52) in lysosomes was altered by D-GalN administration. Only the lysoapoptase-52 was released dose-dependently into the cytoplasm by the treatment, while 18kDa-lysoapoptase was kept constant in the lysosomes. As the results, lysoapoptase-52 in the cytoplasm increased quantitatively and activated procaspase-3 to the active caspase-3 in the cytoplasm, which in turn induced hepatocyte apoptosis and also elevation of the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) . When tea-catechin was administred with D-GalN, the lysoapoptase-52 release into the cytoplasm was suppressed significantly. As the result, the active caspase-3 in the cytoplasm was decreased and the serum AST and ALT activities were also not elevated. However, treatment of CA-074 or E-64 could not protected these phenomena.
収録刊行物
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- ビタミン
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ビタミン 76 (5-6), 283-289, 2002
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680760330112
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- NII論文ID
- 110002842957
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 6191725
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
