S-Carbalkoxythiamine類にかんする研究 : (III)S-Carbalkoxythiamine類の生物学的性質

DOI

書誌事項

タイトル別名
  • STUDIES ON S-CARBALKOXYTHIAMINES : (III) BIOLOGICAL PROPERTIES OF S-CARBALKOXYTHIAMINES

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抄録

Some biological properties of S-carbethoxythiamine (CET), S-carbobutoxythiamine (CBT) and O, S-dicarbethoxythiamine (DCET) were studied. CBT and DCET showed a thiamine activity approximately equivalent to that of thiamine-HCl in the rat growth tests, while CET showed somewhat less activity in the low dose level (5μg). However, it exerts thiamine activity almost equivalent to that of the others in a high dose (10μg). These S-carbalkoxythiamines (CATs) were highly absorbed from the gastrointestinal tract when administered orally to the rabbit, rat and human, and readily converted to thiamine or cocarboxylase in the body. When they were given parenterally to animals, the high blood thiamine levels continued for a long time. CATs penetrated the blood cell membrane more readily than thiamine-HCl, and they were converted to thiamine in the blood cell.

収録刊行物

  • ビタミン

    ビタミン 25 (6), 483-488, 1962

    公益社団法人 日本ビタミン学会

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