Relation of Thyroid Function to NAD Synthesis in Mouse Liver

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  • ADACHI Toru
    Department of Medical Chemistry, National Institute of Hygienic Sciences

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Other Title
  • マウス肝臓中のNAD合成と甲状腺機能の関係
  • マウス カンゾウ チュウ ノ NAD ゴウセイ ト コウジョウセン キノウ ノ カンケイ

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Description

Effects of daily subcutaneous injection of antithyroid agents or thyroxin on change of the level of NAD in mouse liver after intraperitoneal injection of nicotinamide were examined. Injection of 1-methyl-2-mercaptoimidazole, an antithyroid agent, once a day for 2 weeks resulted in higher level of NAD for longer duration. Injection of thyroxin once a day for 8 days gave the contrary results; lower increase of NAD-level after injection of either nicotinamide or NiA. Effects of Some tranquilizers and central nervous system stimulants were also examined. Trifluoperazine, a tranquilizer, gave the similar results to reserpine, higher and longer increase of NAD after NiAA injection.

Journal

  • VITAMINS

    VITAMINS 42 (6), 364-368, 1970

    THE VITAMIN SOCIETY OF JAPAN

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