コエンザイムAの生化学的研究 : PhosphotransacetylaseにたいするCoAの構造特異性について

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書誌事項

タイトル別名
  • Biochemical Studies on Coenzyme A : STRUCTURAL SPECIFICITY OF COENZYME A FOR PHOSPHOTRANSACETYLASE
  • コエンザイム A ノ セイカガクテキ ケンキュウ Phosphotransacetylase ニ タイスル CoA ノ コウゾウ トクイセイ ニ ツイテ
公開日
1971
DOI
  • 10.20632/vso.44.1_1
公開者
公益社団法人 日本ビタミン学会

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説明

Based on the findings during the course of studies on biosynthetic pathway and chemical synthesis of CoA, the author has been interested in elucidating the structural requirement of CoA for the coenzyme activity. Although the central role of the thiol group in an acyl-transfer system was already established, the function of the pantetheine and the nucleotide moieties of CoA has remained uncertain. The author focussed on the kinetic analysis of the effects of various CoA analogs on a CoA-dependent enzyme phosphotransacetylase. It was concluded that the nucleotide moiety of CoA is important for recognition of this coenzyme by phosphotransacetylase, while the pantetheine moiety may chiefly contribute to the binding strength of CoA with the enzyme.

収録刊行物

  • ビタミン

    ビタミン 44 (1), 1-13, 1971

    公益社団法人 日本ビタミン学会

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