PHOTOOXIDATION OF GLUTATHIONE SENSITIZED BY THE RIBOFLAVIN : (I) CONDITIONS OF REACTION

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  • SONE Kiyohide
    Laboratory of Nutrition, Faculty of Agriculture, Tohoku University
  • KOYANAGI Tatsuo
    Laboratory of Nutrition, Faculty of Agriculture, Tohoku University

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Other Title
  • リボフラビンによるグルタチオンの光酸化増感 : (I)作用条件
  • リボフラビンによるグルタチオンの光酸化増感-1-作用条件
  • リボフラビン ニ ヨル グルタチオン ノ ヒカリ サンカ ゾウカン 1 サヨウ ジョウケン

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Description

The photooxidation of glutathione (GSH) sensitized by the riboflavin and its derivatives under the illumination of ultraviolet light was investigated. The photooxidation of GSH was sensitized by riboflavin, flavinmononucleotide (FMN) and lumiflavin in an atmosphere containing suitable concentration of oxygen, and glutathione disulfide was found as the end product. This photooxidation was highly promoted by the rises of temperature and pH of solution, and followed roughly the time course expected for a first-order reaction. FMN and lumiflavin also promoted the photooxidation of GSH, but as to the flavinadeninedinucleotide these action was not found in both pH of 6.0 and 8.0. At the time of photooxidation of GSH, the photolysis of added riboflavin was observed at pH 7.0 and resulted lumiflavin and trace of lumichrome were found chromatographically.

Journal

  • VITAMINS

    VITAMINS 33 (4), 349-354, 1966

    THE VITAMIN SOCIETY OF JAPAN

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