マクロファージとビタミンE

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タイトル別名
  • Macrophage and Vitamin E
  • マクロファージ ト ビタミン E

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抄録

To clarify the role of vitamin E in the modulation of macrophages, we investigated its effect on O_2^- and PGE_2 production in macrophages. Macrophases isolated from vitamin E-treated rats, and containing an extremely high level of α-tocophrol, showed lower O_2^- and PGE_2 production following stimulation with PMA or calcium ionophore A23187 compared to those of control macrophages. We also investigated the mechanism by which vitamin E inhibits both O_2^- and PGE_2 production in macrophages, by measuring the activities of protein kinase C and phospholipase A_2 in intact macrophages and cell-free homogenate system. Vitamin E did not directly inhibit phospholipase A_2 activity but inhibited phospholipase A_2 activation through phosphorylation and translocation of the enzyme itself in the intracellular signal transduction. From these results, it was concluded that the action of vitamin E was due to indirect inhibition of NADPH oxidase and phospholipase A_2 activities through the signal transduction system such as protein kinase C and intracellular Ca^<2+>.

収録刊行物

  • ビタミン

    ビタミン 68 (12), 699-710, 1994

    公益社団法人 日本ビタミン学会

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