G020042 A self-regulating drug release system driven by chemo-mechanical energy conversion
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- Munkhbayar Munkhjargal
- Tokyo Medical and Dental Univ. Graduate School of Medical and Dental Sciences
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- Hatayama Kohdai
- Tokyo Medical and Dental Univ. Graduate School of Medical and Dental Sciences
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- Matsuura Yuki
- 東京医科歯科大学生体材料工学研究所
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- Miyajima Kumiko
- 東京医科歯科大学生体材料工学研究所
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- Xin Wang
- 東京都立産業技術研究センター
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- Arakawa Takahiro
- 東京医科歯科大学生体材料工学研究所
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- Kudo Hiroyuki
- 東京医科歯科大学生体材料工学研究所
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- Kohji Mitsubayashi
- 東京医科歯科大学大学院医歯学総合研究科生体材料工学研究所
Bibliographic Information
- Other Title
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- G020042 化学・力学的エネルギー変換を利用した自律型薬物放出システム([G02004]バイオエンジニアリング部門一般セッション(4))
Abstract
A novel self-regulating drug release system was fabricated and tested. The system consists of two units: decompression unit so-called "organic engine" and drug release unit. Glucose oxidase (GOD) immobilized membrane was utilized to "organic engine" for converting chemical energy of the glucose to mechanical work as a pressure changes of consumed oxygen in the GOD reaction. Pressure changes caused by GOD reaction of the decompression unit was in good correlation to the glucose concentrations. Afterward, the drug release unit which utilizes the energy of the "Organic engine" as a power source was fabricated and evaluated by recording its release actions. The system was then fabricated by combining the both units. As an evaluation result of the system, the feasibility of feedback control of glucose concentration by the chemo-mechanical drug release system was shown.
Journal
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- The Proceedings of Mechanical Engineering Congress, Japan
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The Proceedings of Mechanical Engineering Congress, Japan 2011 (0), _G020042-1-_G020042-3, 2011
The Japan Society of Mechanical Engineers
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Details 詳細情報について
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- CRID
- 1390282680817400064
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- NII Article ID
- 110009758732
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- ISSN
- 24242667
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed