J1620304 Drug-release machine using energy conversion of chemical energy of glucose

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  • J1620304 グルコースの化学エネルギーを用いた薬物放出マシン([J162-03]医療・健康・福祉のためのセンシングおよびロボティクス(3))

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In this work, performance of a decompression unit which converts chemical energy of glucose to mechanical energy for a drug-release machine system was enhanced by a structural modification. This unit was fabricated by separating a cell into top (gas phase) and bottom (liquid phase) parts by glucose oxidase (GOD) immobilized membrane. Chemo-mechanical energy conversion in the organic engine was improved by increasing the reactive area of the enzyme-immobilized membrane and modifying the volume of the gas chamber. The volume of the gas chamber was reduced by reducing its depth, and the area of membrane (2.84 to 11.35 cm^2) for reactive area per volume of gas chamber was increased about 4-fold. In the improved decompression unit, decompression rate of-7.2 Pa・cm/sec was established at lower glucose concentration (25 mmol/l) compared with the previous one. Similarly, actuation of the drug-release machine system by the improved decompression unit resulted in the same mechanical work at 25 mmol/l glucose solution.

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