J2220206 Fabrication of tip-separable microneedles for trans-dermal drug delivery systems

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  • J2220206 次世代経皮吸収製剤を目指した先端分離型マイクロニードルの開発

Abstract

A sharp tip-separable microneedle device for trans-dermal drug delivery systems (DDSs) is developed by MEMS technologies. At first, a Si microneedle was fabricated by applying a photolithography and anistropic wet etching of KOH. Then, a tip-separable microneedle device was produced by the molding process. A sharp tip-separable microneedle device is composed of a sharp tip containing medicine and a supporting base. It has a hook structure between them to separate the tip after its penetration into the skin. Thanks to the hook, the tips penetrated into the skin surface are easily separated and placed in the skin inside by removing the supporting base. It has an advantage that medicine injection time drastically decreases by separating the tip into the skin inside. We evaluated the penetration performanceof eight-sided and rounded knife-edge Si pyramids, as a shape of the tip structure. We inserted them into an artificial skin of a silicone rubber sheet and confirmed that the eight-sided Si pyramid had a larger displacement than the rounded knife-edge one at the same applied load. Thus, we used the eight-sided pyramid shape for a sharp tip-separable microneedle device. Thanks to the sharpness of the Si microneedles, sharp biodegradable tips with the radius of 500 nm could be fabricated.

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