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- 北岡 裕子
- 株式会社JSOLエンジニアリング事業部
書誌事項
- タイトル別名
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- 1E25 Theoretical investigations regarding bronchodilators to the obstructive lung diseases by the use of 4D lung model and computational fluid dynamics
抄録
It is well known that beta-adrenergic agonist bronchodilators result in transient decreases in PaO2 levels in spite of bronchodilation. On the other hand, anticholinergic bronchodilators have been shown to have no effects on arterial blood gases. We hypothesized that the bronchodilation might alter oxygen transport from the trachea to alveoli, because the oxygen transport in the airway is governed by convection rather than diffusion. We constructed a 4D finite element lung model in which one subacinus (= the airspace supplied air by one last respiratory bronchiole) and its entire airway was included. Other lung regions were modeled as cubic sets whose side lengths were equal to their air-supplying bronchi. The lung model was moved during two seconds so that the air went into the lung from the tracheal upper open end at a constant flow rate at upright posture. By Solving incompressible Navier-Stokes equation and oxygen diffusion equation simultaneously, oxygen concentration distribution within the airway was computed. The small-airway dilation reduced oxygen concentration by 40% in average. Meanwhile, the large-airway dilation little changed it. This was because the air velocity at periphery was decrease by the small-airway dilatation, and oxygen transport there was performed only by diffusion. These results have indicated that the small-airway dilation itself decreases the arterial blood oxygen level.
収録刊行物
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- バイオエンジニアリング講演会講演論文集
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バイオエンジニアリング講演会講演論文集 2016.28 (0), _1E25-1_-_1E25-5_, 2016
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390282680853549184
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- NII論文ID
- 110010052070
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- ISSN
- 24242829
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可