2E13 Patho-engineering Analysis of Human Cerebral Aneurysms : Study on Thinning Mechanism by infrastructure

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  • 2E13 ヒト脳動脈瘤の病理工学的検討 : 超微細構造による菲薄化メカニズムに関する検討

Abstract

This research investigated the properties of endothelial cells and wall structure of unruptured cerebral aneurysms to aim elucidation of cerebral aneurysm growth mechanism. Seven aneurysms were categorized into blood blister-like (under 80 μm), transition (80-100 μm), and hypertrophic (above 100 μm) lesion by its thickness and each lesion was observed with transmission electron microscope. The results showed that endothelial cell and wall property both improves as the thickness increases. In addition, number of layers constructing the aneurysm wall increased as the thickness increased. These results suggested that existence of endothelial cell may induce the thickening process of cerebral aneurysms and part of the thickening process may be creation of new layer from migration of smooth muscle cells and creation of fibrous layer.

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