7AM2-A-7 FABRICATION OF ROUNDED KNIFE-EDGED STRUCTURE FOR TRANS-DERMAL DRUG DELIVERY SYSTEM

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  • 7AM2-A-7 経皮吸収剤応用を目的としたナイフエッジ型マイクロニードルの開発(7AM2-A バイオMEMS(センサシンポジウムとの合同セッション))

Abstract

We propose a rounded knife-edge structure having a large surface area to increase the dosage amount in the trans-dermal drug delivery system. We fabricated a Si rounded knife-edge structure as the original master by anisotropic wet etching. We then replicated the same shape with biodegradable hyaluronic acid-based material by a molding process. We evaluated the penetration performance of the fabricated knife-edged structures into an artificial skin of a silicone rubber sheet and confirmed that both the Si and biodegradable knife-edged structures successfully penetrated the sheet with an applied load of 180 g. We also fabricated an arrayed biodegradable rounded knife-edged structure that successfully penetrated mouse skin.

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