書誌事項
- タイトル別名
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- 715 Analysis of Stiffness for Actin Filament under Tensile Force Using Molecular Dynamics Simulation
抄録
Biomechanical factors are considered as crucial modulating factors in dynamic actin polymerization and depolymerization. From this view, it is important to investigate mechanical behavior of actin filament under the influence of various mechanical condition induced by tensile force and structure deformation. The aim of this study is to investigate method of calculating stiffness of actin filament structure. For this purpose, we performed steered molecular dynamics (SMD) simulation in order to study molecular response based on a two-spring model connected in series. Using this method, we calculated stiffness of actin filament subject to tensile force along its longitudinal axis. The results showed that an elastic behavior was observed in elongation range of 0-0.12% actin filament consisting of 14 actin molecules and in this region stiffness for actin filament depended on tensile velocity. We estimated by extrapolation that the stiffness for 1-μm-long actin filament was 57.8 [pN/nm] under condition in which tensile force is applied slowly enough. The order of this simulation agreed with that of experimental results.
収録刊行物
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- 年次大会講演論文集
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年次大会講演論文集 2006.5 (0), 231-232, 2006
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390282681038190592
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- NII論文ID
- 110006635515
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- ISSN
- 24331325
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可