The purpose of this article is to analyze the dynamism of the modern U.S. industrial structure mainly connected with the process of the growth of the service sector, informationization, and external economy. This paper analyzes the industrial diversification process in the Seattle metropolitan area as a case study of these processes. Furthermore, we discuss the importance and possibility of sustainable regional industrial and labor policy in the global era on the basis of the Seattle case study. In the 1980s, changes in the industrial composition occurred in the U.S. The relative position of the manufacturing industry decreased, while the service and financial industries grew. The aerospace and software industries are integral parts of Seattle's industrial composition and the position of both changed dynamically after the 1990s. Aerospace industry reduced as a result of restructuring of Boeing after the Cold War and IT service industry, mainly software industry, grew rapidly instead. The agglomeration and growth of Microsoft and small- and medium-sized software companies contributed to this phenomenon and were encouraged by the following factors. First, software companies regard skillful software engineers as very important resources. Second, the charm of Seattle as a place to live attracts both company founders and skillful software engineers. Third, a key local trade group (Washington Technology Industry Association, WTIA) provides useful programs such as co-buying of health care programs to software companies. We can think of these programs by WTIA as virtual local industrial policies. In the 2000s, the growth of U.S. industry and employment were delayed by a decrease in the number of the manufacturing industry employees. The software industry jumped to the position of leading Seattle industry, and software engineers living in Seattle formed the base of new industry creation, including the biotechnology and interactive media. Finally, the growth of the IT service industry in Seattle brought an increase in household income in the high-ranking range as well as globalization of the Seattle labor market. Both state and city industrial and labor policies are changing in Seattle in response to the changes in both industry and work force needs. This paper discusses the characteristics of these policies, and shows the importance and effects of community and local government-led actions on globalization.