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47 ISOLATION AND STRUCTURE ELUCIDATION OF PAMAMYCIN-607, AN AERIAL MYCELIUM-INDUCING SUBSTANCE OF STREPTOMYCES ALBONIGER
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- Kondo Satoru
- Department of Agricultural Chemistry, Nagoya University
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- Marumo Shingo
- Department of Agricultural Chemistry, Nagoya University
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- Kondo Tadao
- Chemical Instrument Center, Nagoya University
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- Hattori Hiroyuki
- National Institute for Basic Biology
Bibliographic Information
- Other Title
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- 47 Streptomyces albonigerの気菌糸誘導物質Pamamycin-607の単離と構造
Description
Actinomycetes produce a number of useful antibiotics. The productivity of some antibiotics was recently shown to be closely correlated to the cell differentiation of actinomycetes, such as aerial mycelium formation and sporulation. We have isolated an aerial mycelium-inducing substance, named pamamycin-607, from the cultured material of Streptomyces alboniger, a puromycin producer, and its structure elucidated by means of spectral analysis. The physicochemical properties of pamamycin-607 are colorless oil, C_<35>H_<61>NO_7(HR-MS obsd. m/z 607.4462, error 1.4), [α]^<33>_D+22.8°(c=0.26, MeOH), UVλ^<MeOH>_<max> 215 nm (ε470), IRν^<CHCl_3>_<max> 1740 cm^<-1> (-O-CO-). The structure elucidation of pamamycin-607 was carried out mainly on its trifluoroacetic acid salt that was extensively analyzed by ^1H and ^<13>C NMR, 500 MHz 2D NMR spectra (^1H-^1H and ^1H-^<13>C shift correlation 2D and 2D-J spectra) with the aid of proton spin decoupling and NOE difference spectra. The structure of pamamycin-607 with the relative stereochemistry has thus been elucidated as shown in Fig. 1. The proposed structure seems to be a novel ionophore compound with a 16-membered macrodiolide ring having a dimethylamino side chain. Pamamycin-607 induced the aerial mycelium formation at 0.1 μg/disc to the aerial mycelium negative strain of Streptomyces alboniger.
Journal
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- Symposium on the Chemistry of Natural Products, symposium papers
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Symposium on the Chemistry of Natural Products, symposium papers 27 (0), 351-358, 1985
Symposium on the Chemistry of Natural Products Steering Committee
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Details 詳細情報について
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- CRID
- 1390282681050595840
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- NII Article ID
- 110006678479
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- ISSN
- 24331856
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed