P-15 ヤマブシタケ(Hericium erinaceum)から得られた小胞体ストレスによる細胞死阻害物質(ポスター発表の部)
書誌事項
- タイトル別名
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- P-15 New hericenones including a protective agent against ER stress-dependent Neuro2a cell death from the medicinal mushroom of Hericium erinaceum(Poster Presentation)
説明
The importance of the endoplasmic reticulum (ER) in triggering a specific program of cell death has been recently reported. By triggering apoptosis on neural cells, ER-stress is a major cause of neurodegenerating disease such as Alzheimer disease. The demand for new protective substances to the ER-stress-dependent cell death prompted us to screen the protective activity of mushrooms. On the course of the screening, we isolated new hericenones, 3-hydroxy-hericenone F as a protective agent, along with related compounds, hericenone I and J. The structures of hericenones were determined by NMR and MS spectra. The structure of 3-hydroxy hericenone was elucidated as (8-formyl-3-hydroxy-5-methoxy-2-methyl-2-(4'-methyl-2'-oxopent-3'-enyl) chroman-7-yl) methyl palmitate, which had one additional hydroxy group compared to hericenone F. 3-Hydroxy-hericenone F showed the protective activity dose-dependently, however hericenones F, I and J did not have any activity at the concentration of 10μg/mL. Therefore, we suggested that the hydroxy group of 3-hydroxy-hericenone F was important for the protective activity. This is the first report of a new hericenone which has the protective activity against ER stress-dependent cell death. The further study using more hericenones is needed for the understanding of the structure-activity relationship.
収録刊行物
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- 天然有機化合物討論会講演要旨集
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天然有機化合物討論会講演要旨集 50 (0), 309-314, 2008
天然有機化合物討論会実行委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681055336576
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- NII論文ID
- 110007066744
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- ISSN
- 24331856
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
