Synthetic Studies on Zetekitoxin AB

DOI

Bibliographic Information

Other Title
  • ゼテキトキシンABの合成研究

Abstract

<p> Zetekitoxin AB (ZTX)　(1), one of a structural related analog of saxitoxin (STX), is a neurotoxin isolated from Ateropus. zeteki., and it shows potent inhibitory activity against voltage-dependent sodium channel. A ZTX (1) has some characteristic structures, which are tricyclic bis-guanidine structure, the same core structure as STX and its analogs, cross-linked macrolactam moiety involving isoxazolidine (at C6-C11), and N-hydroxy carbamate group on N7. Here, we described synthesis of 5 which has core structure of ZTX with quaternary stereogenic center at C11 and isoxazolidine on the side chain at C11. </p>

Journal

Details 詳細情報について

  • CRID
    1390282681055558400
  • NII Article ID
    130006470669
  • DOI
    10.24496/tennenyuki.55.0_posterp-1
  • ISSN
    24331856
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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