Medicinal Flowers: Melanogenesis Inhibitors from the Flower Buds of Camellia japonica and Nelumbo nucifera

DOI

Bibliographic Information

Other Title
  • メディシナルフラワー研究：椿花 (Camellia japonica, 花部) および蓮花 (Nelumbo nucifera, 花部) のメラニン生成抑制成分

Description

<p>In the course of our studies on biofunctional constituents from medicinal flowers, the methanolic extracts from the flower buds of Camellia japonica (Theaceae) cultivated in China (Yunnan province) and Korea (Cheju Island) and Nelumbo nucifera (Nymphaeaceae) cultivated in Thailand (Khon Kaen province) were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the flower buds of C. japonica cultivated in China and Korea, we have isolated 10 new oleanane-type triterpene saponins, sanchakasaponins A–H and camelliosides E and F, together with 12 known saponins. On the other hand, from the flower buds and leaves ofN. nucifera, 12 benzylisoquinoline alkaloids including a new alkaloidwere isolated. Among them, several saponin and benzylisoquinoline alkaloids significantly inhibited melanogenesis. The inhibitory effects were stronger than that of a reference compound, arbutin. Furthermore, the inhibitory effects of related commercial and synthesized alkaloids on melanogenesis were examined and their structure-activity relationships were characterized. In addition, camellioside B, a major constituent of C. japonica cultivated in Japan, were found to display an inhibitory effect on melanogenesis, but an enhancing effect on fibroblast proliferation. This biological selectivity could make camellioside B useful for treating skin disorders.</p>

Journal

Details 詳細情報について

  • CRID
    1390282681055566208
  • NII Article ID
    130006470673
  • DOI
    10.24496/tennenyuki.55.0_posterp-6
  • ISSN
    24331856
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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