41 13-オキシインゲノール類の全合成(口頭発表の部)
書誌事項
- タイトル別名
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- 41 Total Synthesis of 13-Oxyingenols(Oral Presentation)
抄録
13-Oxyingenol derivative 1 and ingenol (3) are diterpenoids isolated from the plants of Euphorbia sp. The main structural features of ingenols are a bicyclo[4.4.1]undecane skeleton with inside-outside intrabridgehead stereochemistry and a high degree of oxygenation. They and their analogues showed interesting bioactivities. The molecular complexity of ingenol derivatives, in conjunction with their potent bioactivities, has made them attractive synthetic targets. We have achieved the first total synthesis of (-)-13-oxyingenol (2) and its natural derivative 1. The efficient functionalization of the A- and B-ring parts was established by using C-2 and C-7 hydroxy groups as clues. This approach is highlighted by RCM for the construction of an inside-outside framework, regio- and stereoselective dihydroxylation for the functionalization of the A-ring, and [2,3]-sigmalropic rearrangement for the functionalization of the B-ring.
収録刊行物
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- 天然有機化合物討論会講演要旨集
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天然有機化合物討論会講演要旨集 54 (0), 241-246, 2012
天然有機化合物討論会実行委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681056354176
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- NII論文ID
- 110010013834
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- ISSN
- 24331856
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可