Changes of Intestinal Mucosal and Plasma PYY in a Diarrhea Model Rat and Influences of Loperamide as the Treatment Agent for Diarrhea

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  • HIROTANI Yoshihiko
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohatani University Department of Pharmacy, Osaka University Hospital
  • MIKAJIRI Kyoko
    Department of Pharmacy, Osaka University Hospital Department of Hospital Pharmacy, School of Medicine, Keio University
  • IKEDA Kenji
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohatani University Department of Pharmacy, Osaka University Hospital
  • MYOTOKU Michiaki
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohatani University
  • KUROKAWA Nobuo
    Department of Pharmacy, Osaka University Hospital

Bibliographic Information

Other Title
  • 下痢モデルラット腸管組織内及び血漿中 Peptide-YY (PYY) の変動とその治療薬 Loperamide の影響
  • ゲリ モデル ラット チョウカン ソシキナイ オヨビ ケッショウチュウ Peptide YY PYY ノ ヘンドウ ト ソノ チリョウヤク Loperamide ノ エイキョウ

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Description

  Peptide YY (PYY) is produced by endocrine cells in the lower gastrointestinal tract. The main functions of PYY are antisecretory effects in the colon and inhibition of gastrointestinal motility. We chose PYY as an index of the intrinsic factor in diarrhea and examined the influence of changes induced in a diarrhea rat model by administration of 4 types of laxative and loperamide hydrochloride (loperamide) as an agent for the treatment of diarrhea. A specific radioimmunoassay was performed to determine plasma and intestinal mucosal PYY concentrations. PYY in the rat intestinal tissue extract was distributed at a high density in the lower intestinal mucosa. In the diarrhea rat model, multiple changes in PYY concentrations in the intestinal mucosa and plasma were observed. In rats administered castor oil and sodium picosulfate, the intestinal mucosal PYY levels significantly decreased in a dose-dependent manner. Plasma PYY levels significantly decreased only in rats administered magnesium citrate. Next, we examined the influence of loperamide administration on the intestinal mucosa and plasma PYY concentrations in these rats. Loperamide administration resulted in multiple changes in plasma and intestinal mucosa PYY concentrations, along with an improvement in the diarrhea. Our research showed that the endocrine hormone PYY is involved in the onset of diarrhea, the course of the condition, and the manifestation of medicinal effects in the lower intestine.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128 (9), 1311-1316, 2008-09-01

    The Pharmaceutical Society of Japan

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