Effect of Oral Hypoglycemic Agents on Gastric Secretion

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Other Title
  • 胃液分泌動態におよぼす経口糖尿病薬の影響
  • イエキ ブンピ ドウタイ ニ オヨボス ケイコウ トウニョウビョウヤク ノ エ

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Description

The effect of oral hypoglycemic agents on gastric secretion was studied in alloxan diabetic rabbits. Peptic activity was measured with bovine haemoglobin as substrate, as reported in the Committee to Discuss the Determination of Gastric Juice in the Gastroenterological Society of Japan. Gastric acidity was estimated by Topfer-Michaelis' method. Blood sugar was determined by using Glucose B-Test, while amylase activity in blood was determined by use of Amylase Test. Buformin hydrochloride, glymidine sodium and glyclopyramide were used as a hypoglycemic agent. Gastric secretion volume, gastric peptic activity, pepsin and acid output reached the maximum at 3-4 hours after the administration of hypoglycemic agents, which was related to blood sugar level. Free and total gastric acidity and amylase activity in blood were not significantly affected. Among the effects of these three drugs on the peptic activity, pepsin output, and blood sugar level after their respective oral administration, we could find some significant differences.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (4), 354-359, 1981

    The Pharmaceutical Society of Japan

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