Structural and Functional Properties of the C-terminal Region of Mitochondrial ADP/ATP Carrier
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- SHINOHARA Yasuo
- Institute for Genome Research, University of Tokushima Faculty of pharmaceutical Science, University of Tokushima
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- HASHIMOTO Mitsuru
- Faculty of pharmaceutical Science, Matsuyama University
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- KIHIRA Yoshitaka
- Institute of Health Biosciences, University of Tokushima
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- OHKURA Kazuto
- Faculty of Pharmacy, Chiba Institute of Science
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- MAJIMA Eiji
- Protenova, Inc.
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- TERADA Hiroshi
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
Bibliographic Information
- Other Title
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- ミトコンドリア内膜のADP/ATP透過担体のC末端領域の構造特性と機能
- ミトコンドリア ナイ マク ノ ADP ATP トウカ タンタイ ノ C マッタン リョウイキ ノ コウゾウ トクセイ ト キノウ
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Abstract
Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of this protein. Next, we describe the results of our recent studies on the difference in the C-terminal region between yeast type 2 AAC isoform and bovine type 1 AAC isoform. Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 130 (2), 199-204, 2010-02-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681103501824
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- NII Article ID
- 130000171288
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 10545162
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed