Field Survey of the Anticancer Drug Contamination in the Preparation Environment<br/>~Usefulness of the 5-FU Monitoring by the Coupon Method~
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- Sato Junya
- Department of Pharmacy, Iwate Medical University Hospital Department of Clinical Pharmaceutics, School of Pharmacy, Iwate Medical University
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- Mori Megumi
- Department of Pharmacy, Iwate Medical University Hospital
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- Sasaki Takuya
- Department of Pharmacy, Iwate Medical University Hospital
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- Nihei Satoru
- Department of Pharmacy, Iwate Medical University Hospital
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- Kumagai Masumi
- Department of Nursing, Iwate Medical University Hospital
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- Nakayama Seiya
- Shionogi Analysis Center Co., Ltd.
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- Takahashi Katsuo
- Department of Pharmacy, Iwate Medical University Hospital Department of Clinical Pharmaceutics, School of Pharmacy, Iwate Medical University
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- Kudo Kenzo
- Department of Pharmacy, Iwate Medical University Hospital Department of Clinical Pharmaceutics, School of Pharmacy, Iwate Medical University
Bibliographic Information
- Other Title
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- 抗がん剤調製環境における汚染調査<br/>~クーポン法による5-FUモニタリングの有用性~
- 抗がん剤調製環境における汚染調査 : クーポン法による5-FUモニタリングの有用性
- コウガンザイ チョウセイ カンキョウ ニ オケル オセン チョウサ : クーポンホウ ニ ヨル 5-FU モニタリング ノ ユウヨウセイ
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Abstract
For medical professionals involved in cancer chemotherapy, occupational exposure of anticancer agents is considered a health risk. Education about the handling of anticancer drugs and proper use of protective equipment are important for reducing occupational exposure of anticancer drugs. Furthermore, monitoring of the contamination level of anticancer drugs is important for determining the propriety of anti-contamination methods. Cyclophosphamide (CPA) has been used as the standard drug of the contamination level; however, it is rarely detected because of the disparity between drug preparation frequency and consumption, and use of a closed system. Therefore, we chose 5-fluorouracil (5-FU) as the standard drug and attempted to monitor its contamination levels by sampling using drug absorption sheets (the coupon method). We measured contamination levels inside a biological safety cabinet (BSC) and at its lower floor, and at a preparation worktable, nurses' station worktable, its lower floor and floor of the hospital room in a chemotherapy room for outpatients of the Iwate Medical University Hospital for 3 time periods. 5-FU was detected in 72% of the coupons (n=108), while CPA was detected in only 7% of the coupons (n=108). Monitoring of 5-FU contamination levels by using the coupon method was considered useful for evaluating anti-contamination method and the contamination process.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 134 (6), 751-756, 2014
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681103525504
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- NII Article ID
- 130004427990
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- NII Book ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC2cjot1KjtQ%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 025583408
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- PubMed
- 24882652
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed