アミド誘導体としての芳香族カルボン酸のガスクロマトグラフィー

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書誌事項

タイトル別名
  • Gas Chromatography of Aromatic Carboxylic Acids as Their Amide Derivatives
  • アミド ユウドウタイ トシテノ ホウコウゾク カルボンサン ノ ガス クロマト

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抄録

A method for the quantitative determination of salicylic acid and benzoic acid by gas chromatography with flame thermionic detector was developed. The carboxylic acids were converted into the corresponding amides with isopropylamine by mixed carbonic anhydride method. The reaction was performed quantitatively in chloroform in the presence of triethylamine and ethyl chlorocarbonate, and less than 30 min was required for a quantitative derivatization. This method permitted the determination of the drugs at serum levels down to 20-30 ng/ml.

収録刊行物

  • 薬学雑誌

    薬学雑誌 101 (11), 1055-1058, 1981

    公益社団法人 日本薬学会

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