Hybrid Liposomes as a Drug Carrier for the Oral Administration of Insulin in Diabetic Rats

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  • 糖尿病モデルラットを用いたインシュリン含有複合脂質膜の経口治療に関する基礎的研究
  • トウニョウビョウ モデル ラット オ モチイタ インシュリン ガンユウ フクゴウ シシツ マク ノ ケイコウ チリョウ ニ カンスル キソテキ ケンキュウ

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Abstract

  It is known that hybrid liposomes composed of dimyristoylphosphatidylcholine (DMPC) and micellar surfactant (Tween 20) are effective for encapsulating drugs and for the treatment of meningeal gliomatosis in vivo without toxicity. In this study, we attempted to use these hybrid liposomes as a drug carrier system for the oral administration of insulin using diabetic model rats. The noteworthy aspects were as follows: (a) The hybrid liposomes of 90 mol% DMPC/10 mol% Tween 20 were stable and uniform for more than 4 weeks. (b) The blood glucose level of diabetic model rats decreased after the oral administration of hybrid liposomes including insulin. These results suggest that the oral administration of hybrid liposomes including insulin should be effective for the treatment of diabetes.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 124 (4), 231-235, 2004-04-01

    The Pharmaceutical Society of Japan

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