Ameliorative Effect of Propolis on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

DOI IR Web Site Web Site 3 Citations 24 References
  • ZAMAMI Yoshito
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • FUJIWARA Hiroki
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • HOSODA Miho
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • HINO Hayato
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • HIRAI Kazuhiro
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • OKAMOTO Kazuaki
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • JIN Xin
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • TAKATORI Shingo
    Research Laboratories Kyoto, Nippon Shinyaku Co., Ltd.
  • DOI-TAKAKI Shima
    Department of Research and Development, Yamada Apiculture Center, Inc.
  • KAWASAKI Hiromu
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Bibliographic Information

Other Title
  • Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用
  • Propolis チョウキ トウヨ ニ ヨル Otsuka Long Evans Tokushima Fatty OLETF ラット ノ インスリン テイコウセイ カイゼン サヨウ

Search this article

Abstract

  Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 130 (6), 833-840, 2010-06-01

    The Pharmaceutical Society of Japan

Citations (3)*help

See more

References(24)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top