Chemistry and Biological Activity of Nucleoside Q and Its Analogs

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Other Title
  • Nucleoside Qおよび類縁体の化学と生物活性
  • Nucleoside Q オヨビ ルイエンタイ ノ カガク ト セイブツ カッ

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Description

Nucleoside Q was found in the first position of anticodon in some transfer ribonucleic acids (tRNAs). Total synthesis of the nucleoside Q and its diastereomer made it possible to determine relative and absolute configurations of nucleoside Q. An unusual posttranscriptional modification mechanism in the biosynthesis of nucleoside Q was found by Nishimura et al. by using our synthetic nucleoside Q derivatives. A deficiency of Q in tRNAs is related to tumor growth. Some cancer cells contain tRNAs having G in place of Q ; Q base administered can be incorporated into these tRNAs. Two anticancer antibiotics having such 7-deazapurine nucleus as cadeguomycin and kanagawamicin were found and the former was synthesized.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 104 (4), 317-324, 1984

    The Pharmaceutical Society of Japan

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