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- 樽井 敦
- 摂南大学薬学部
書誌事項
- タイトル別名
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- Stereoselective Synthesis of Multi-substituted Fluoro-β-lactams and Their Conversion to Fluorinated β-Amino Acid Core
- タチカン フルオロ-v-ラクタムルイ ノ リッタイ センタクテキ ゴウセイ ト ガン フッソv-アミノサン コッカク エ ノ ヘンカン
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抄録
Multi-substituted β-lactam compounds have not only attracted considerable interest as core structures of pharmaceutical compounds such as antibiotics but also have been used as building blocks for the construction of β-amino acids. Electrophilic β-lactams can be used to enhance essential biological activities. Furthermore, the ring-opening reactions of electrophilic β-lactams can be used to provide facile access to β-amino acids. The introduction of an electronegative fluorine atom to a β-lactam ring to give the corresponding fluoro-β-lactam can be used as an effective strategy for the preparation of electrophilic β-lactams. In this review, we provide a summary of our recent research towards the direct functionalization of fluoro-β-lactams. This review has been divided into four topics, including: 1) the alkylation and hydroxyalkylation of α-bromo-α-fluoro-β-lactams (1); 2) the nickel-catalyzed cross coupling reaction of 1; 3) the asymmetric synthesis of fluoro-β-lactams using chiral ligands; and 4) the utilization of fluoro-β-lactams as highly electrophilic building blocks.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 135 (11), 1245-1253, 2015-11-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681104062080
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- NII論文ID
- 130005105495
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 026851735
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- PubMed
- 26521873
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可