Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type <i>Cannabis</i>

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  • Takeda Shuso
    Department of Molecular Biology, Daiichi University of Pharmacy

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Other Title
  • 繊維型大麻草主成分カンナビジオールを基盤としたメディシナルケミストリー
  • センイガタ タイマソウ シュセイブン カンナビジオール オ キバン ト シタ メディシナルケミストリー
  • Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis

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Abstract

  Considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, and it has been reported to possess diverse biological activities. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), several studies have investigated whether CBDA itself is biologically active. In the present report, the author summarizes findings indicating that; 1) CBDA is a selective cyclooxygenase-2 (COX-2) inhibitor, and ii) CBDA possesses an anti-migrative potential for highly invasive cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Further, the author introduces recent findings on the medicinal chemistry and pharmacology of the CBD derivative, CBD-2′,6′-dimethyl ether (CBDD), that exhibits inhibitory activity toward 15-lipoxygenase (15-LOX), an enzyme responsible for the production of oxidized low-density lipoprotein (LDL). These studies establish CBD as both an important experimental tool and as a lead compound for pharmaceutical development. In this review, the author further discusses the potential uses of CBD and its derivatives in future medicines.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 133 (10), 1093-1101, 2013-10-01

    The Pharmaceutical Society of Japan

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