ラット脳細胞の初代培養系を用いてグルコースの取り込み活性でみたアートセレブ脳脊髄手術用洗浄灌流液の薬理学的評価

DOI NDLデジタルコレクション Web Site Web Site 被引用文献3件 参考文献4件

書誌事項

タイトル別名
  • Pharmacological Assessment of ARTCEREB Irrigation and Perfusion Solution for Cerebrospinal Surgery Based on Glucose Incorporation Activity in Primary Cultures of Rat Brain Cells
  • ラット ノウ サイボウ ノ ショダイ バイヨウケイ オ モチイテ グルコース ノ トリコミ カッセイ デ ミタ アートセレブ ノウ セキズイ シュジュツヨウ センジョウカンリュウエキ ノ ヤクリガクテキ ヒョウカ
公開日
2010
DOI
  • 10.1248/yakushi.130.127
公開者
公益社団法人 日本薬学会

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説明

ARTCEREB® irrigation and perfusion solution (Artcereb) is typically used as an artificial fluid for applications inside the skull and spinal cavity. This in vitro study was conducted to assess the effects of Artcereb in cultures of rat fetal brain cells. Cell function following exposure to Artcereb was evaluated by measuring 3H-deoxy-D-glucose incorporation activity. Cell function was significantly reduced in primary cultures of rat fetal brain cells at 0 h and 24 h after 1-h or 3-h exposure to normal saline as compared with Artcereb. Cell function was also significantly reduced at 24 h after 3-h exposure to lactated Ringer's solution as compared with Artcereb. Furthermore, cell function was significantly reduced at 24 h after 3-h exposure to a modified Artcereb formulation lacking either HCO3- or Mg2+ as compared with Artcereb, while cell function was unaffected at 24 h after exposure to lactated Ringer's solution with HCO3- or normal saline with HCO3- as compared with Artcereb. These findings suggest the importance of the presence of HCO3- and Mg2+ in the formulation of Artcereb.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 130 (1), 127-130, 2010

    公益社団法人 日本薬学会

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