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- 武田 厚司
- 静岡県立大学薬学部医薬生命化学教室
書誌事項
- タイトル別名
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- Essential Trace Metals and Brain Function
- セイタイ ビリョウ キンゾク ノ サヨウ ニ チャクモク シタ ノウ キノウ カイセキ ト ノウ シッカン ノ ヨボウ
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説明
Trace metals such as zinc, manganese, and iron are necessary for the growth and function of the brain. The transport of trace metals into the brain is strictly regulated by the brain barrier system, i.e., the blood-brain and blood-cerebrospinal fluid barriers. Trace metals usually serve the function of metalloproteins in neurons and glial cells, while a portion of trace metals exists in the presynaptic vesicles and may be released with neurotransmitters into the synaptic cleft. Zinc and manganese influence the concentration of neurotransmitters in the synaptic cleft, probably via the action against neurotransmitter receptors and transporters and ion channels. Zinc may be an inhibitory neuromodulator of glutamate release in the hippocampus, while neuromodulation by manganese might mean functional and toxic aspects in the synapse. Dietary zinc deficiency affects zinc homeostasis in the brain, followed by an enhanced susceptibility to the excitotoxicity of glutamate in the hippocampus. Transferrin may be involved in the physiological transport of iron and manganese into the brain and their utilization there. It is reported that the brain transferrin concentration is decreased in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease and that brain iron metabolism is also altered. The homeostasis of trace metals in the brain is important for brain function and also for the prevention of brain diseases.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 124 (9), 577-585, 2004-09-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681104230016
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- NII論文ID
- 110003614989
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 7079330
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- PubMed
- 15340179
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可