Lessons Learned after 25 Years of Studies on the Physiological Roles of the Peroxisome Proliferator-activated Receptor
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- Motojima Kiyoto
- Department of Biochemistry, Meiji Pharmaceutical University
Bibliographic Information
- Other Title
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- ペルオキシソーム増殖薬活性化受容体(PPAR)研究の四半世紀—その盛衰の背景と教訓
- ペルオキシソーム増殖薬活性化受容体(PPAR)研究の四半世紀 : その盛衰の背景と教訓
- ペルオキシソーム ゾウショクヤク カッセイカ ジュヨウタイ(PPAR)ケンキュウ ノ ヨン ハンセイキ : ソノ セイスイ ノ ハイケイ ト キョウクン
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Description
The peroxisome proliferator-activated receptor (PPAR) was discovered a quarter of a century ago. PPAR was soon recognized as a general transcriptional regulator of lipid homeostasis, and several hypolipidemic and antidiabetic agents were shown to be effective ligands for it. Since then, many attempts to develop more potent drugs have been made worldwide, but most were unsuccessful due to serious side effects. It appears that the PPAR boom has ended. This review summarizes the short history of PPAR studies, including our own results, and discusses the lessons learned from the rise and fall of studies in this field for next-generation basic studies and drug development research.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 135 (10), 1083-1089, 2015-10-01
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681104279424
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- NII Article ID
- 130005100634
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 026778295
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- PubMed
- 26423862
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed