Effects of Des-Arg<SUP>9</SUP>-bradykinin and Its Kininase II-Hydrolyzing Products on Rat Polymorphonuclear Leucocyte Emigration in Vitro

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  • In VitroにおけるDes-Arg<SUP>9</SUP>-bradykininおよびそのKininaseII水解産物のラット多核白血球遊走におよぼす影響
  • In VitroにおけるDes-Arg9-bradykininおよびそのKininase2水解産物のラット多核白血球遊走におよぼす影響
  • In Vitro ニ オケル Des Arg9 bradykinin オヨビ

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Description

Effects of bradykinin and des-Arg9-bradykinin on rat polymorphonuclear leucocyte (PMNL) emigration were assayed by the modified Boyden chamber method. the ability of des-Arg9-bradykinin of PMNL emigration was about one-half of that of bradykinin in the concentration range of 10-8M to 10-6M. The kininase II-hydrolyzate of bradykinin had only a little ability on PMNL emigration at both concentrations of 10-6M and 10-7M. On the other hand, the kininase II-hydrolyzate of des-Arg9-bradykinin, and Ser-Pro-Phe, which is a hydrolyzing product of des-Arg9-bradykinin by this enzyme, induced the PMNL emigration at 10-6M. These results suggest a possibility that des-Arg9-bradykinin and Ser-Pro-Phe participate in PMNL emigration in inflammatory processes.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 104 (6), 695-698, 1984

    The Pharmaceutical Society of Japan

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