外部刺激応答型人工核酸スイッチの設計と合成

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タイトル別名
  • Design, Syntheses and Properties of Nucleic Acid Switch in Response to External Stimuli
  • ガイブ シゲキ オウトウガタ ジンコウ カクサン スイッチ ノ セッケイ ト ゴウセイ

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抄録

  The control of molecular properties using external stimuli is an attractive research area that offers the potential for regulation of various biological phenomena. This review summarizes the concept, design, syntheses and properties of nucleic acid switches in response to external stimuli, namely, “external-stimuli-responsive bridged nucleic acids monomer”. From 1H-NMR experiments, every external-stimuli-responsive bridged nucleic acid monomer was found to have an N-conformation, while an S-conformation was predominantly observed after exposure to a proper stimulus. Each bridged nucleic acid monomer was effectively introduced into oligodeoxynucleotides using an automated DNA synthesizer. Moreover, oligonucleotides modified with these bridged nucleic acid monomer were changed in their hybridization property and tolerance to enzymatic digestion in response to each stimulus. These results clearly showed that external-stimuli-responsive bridged nucleic acids monomers should work as a nucleic acid switch, and have the potential for regulation of various biological phenomena.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 131 (1), 101-111, 2011-01-01

    公益社団法人 日本薬学会

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