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- 高須 清誠
- 東北大学大学院薬学研究科
書誌事項
- タイトル別名
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- Development of Boomerang-Type Intramolecular Cascade Reactions and Application to Natural Product Synthesis
- ブーメランガタ ブンシ ナイ レンゾク ハンノウ ノ セイミツ セイギョ ト セイリ カッセイ ブッシツ ゴウセイ エ ノ オウヨウ
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Intramolecular cascade reaction has received much attention as a powerful methodology to construct a polycyclic framework in organic synthesis. We have been developing “boomerang-type cascade reaction” to construct a variety of polycyclic skeletons efficiently. In the above reactions, a nucleophilic function of substrates changes the character into an electrophile after the initial reaction, and the electrophilic group acts as a nucleophile in the second reaction. That is, the reaction center stepwise moves from one functional group back to the same one via other functional groups. The stream of the electron concerning the cascade reaction is like a locus of boomerang. We show here three different boomerang-type reactions via ionic species or free radicals. 1) Diastereoselective Michael-aldol reaction based on the chiral auxiliary method and enantioselective Michael-aldol reaction by the use of external chiral sources. 2) Short and efficient total syntheses of longifolane sesquiterpenes utilizing intramolecular double Michael addition as a key step. 3) Development of boomerang-type radical cascade reaction of halopolyenes to construct terpenoid skeletons and its regioselectivity.
収録刊行物
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- 薬学雑誌
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薬学雑誌 121 (12), 887-898, 2001-12-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681104364672
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- NII論文ID
- 110003648496
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD3MXovFWqsLc%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 5992339
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- PubMed
- 11766403
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可