クラリスロマイシンドライシロップと各種カルボシステイン製剤併用時の苦味強度における先発医薬品と後発医薬品間の違い

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タイトル別名
  • Bitterness of the Mixture of Clarithromycin Dry Syrup and Carbocisteine Preparation-difference between Branded and Generic Drugs
  • クラリスロマイシン ドライ シロップ ト カクシュ カルボシステイン セイザイ ヘイヨウジ ノ ニガミ キョウド ニ オケル センパツ イヤクヒン ト コウハツ イヤクヒンカン ノ チガイ

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説明

The purpose of this study was to assess the bitterness intensity and pH of the solutions of clarithromycin dry syrup (CAM-DS), carbocisteine preparation (CC), and the concomitant use of both drugs. We conducted 6 types of human gustatory sensation tests with 6 healthy male volunteers. As a result, there was almost no difference in the bitterness intensity of CAM-DS between the branded (the latest and former preparations) and the generic formulations. The bitterness intensity of CAM-DS (the latest and former preparations of the branded as well as the generic formulations) was almost equally enhanced by mixing it with either the branded CC-DS or the branded and the generic carbocisteine granule (CC-Gr). On this occasion, the enhancing the bitterness of the branded CAM-DS (latest and former preparation) was nearly avoided safely by dosage form's changing CC-DS or CC-Gr to the branded CC-Sy. However, unlike the branded CC-Sy, some generic CC-Sy failed to suppress the bitterness. Furthermore, it was proven that some generic CAM-DS were shown to exhibit bitterness when mixed with even branded CC-Sy. In conclusion, it should be noted that the extent of bitterness of the mixture of CAM-DS and CC highly varies among the generic formulations.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 128 (3), 479-485, 2008-03-01

    公益社団法人 日本薬学会

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