Pharmacological Study on Panax ginseng C. A. MEYER. VII. Protective Effect of Red Ginseng on Infection (1) On Phagocytic Activity of Mouse Reticuloendotherial System

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  • 薬用人参の薬理学的研究(第7報) 紅参の感染防御作用 その1 マウス網内系の貪食活性化作用
  • 薬用人参の薬理学的研究-7-紅参の感染防御作用-1-マウス網内系の貪食活性化作用
  • ヤクヨウ ニンジン ノ ヤクリガクテキ ケンキュウ 7 コウジン ノ カンセン

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Abstract

Effects of 70% methanol extract (I) from Red Ginseng (steamed and dried root of Panax ginseng C. A. MEYER) on the phagocytic activity of mouse reticuloendotherial system were studied by the carbon clearance method in normal mice, carrageenan or cyclophosphamide-treated mice. In normal mice, the clearance-rate of carbon was shortened 1 h after the administration of I (50, 200 or 500 mg/kg, p.o., one time, one time/d for 3 d or one time/d for 5 d). Microscopically, carbon particles were internalized mainly by Kupffer cells in the liver and in the spleen, by macrophage (Mφ) of marginal zones between white and red pulp. I (200 or 500 mg/kg, p.o., one time/d for 3 d) activated the phagocytosis of carbon by Kupffer cells in the liver and Mφ in the spleen. In carrageenan (injurious agent of Mφ)-treated mice, I (200 or 500 mg/kg, p.o.) was not found to show the shortening of the clearance rate of carbon. However, in cyclophosphamide (injurious agent of leukocyte)-treated mice, the clearance-rate of carbon was shortened by the oral administration of I (200 or 500 mg/kg, p.o.). These results suggested that 70% methanol extract from Red Ginseng promotes the phagocytic activity on the reticuloendotherial system in mice and has a stimulatory effect on Mφ.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 105 (10), 948-954, 1985

    The Pharmaceutical Society of Japan

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