Basic Investigation for Classification of Anticancer Drugs by Pharmacological Effects

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  • Takahashi Natsuko
    Graduate School of Medicine, Hokkaido University
  • Kobayashi Masaki
    Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Itagaki Shirou
    Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Hirano Takeshi
    Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Takekuma Yoh
    Laboratory of Phamacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Sugawara Mitsuru
    Laboratory of Phamacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Iseki Ken
    Laboratory of Clinical Pharmaceutics and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University Department of Pharmacy, Hokkaido University Hospital

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Other Title
  • 効果発現パターンにより抗がん薬を分類するための基礎的検討
  • コウカ ハツゲン パターン ニ ヨリ コウガンクスリ オ ブンルイ スル タメ ノ キソテキ ケントウ

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  The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it is necessary to reclassify a great number of anticancer drugs. We propose a new classification system based on pharmacological effects of anticancer drugs. Classification of four anticancer drugs (cisplatin, carboplatin, paclitaxel and gemcitabine) was performed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The four anticancer drugs were grouped by IC50 values (inhibitory concentration, 50%) in a time-dependent manner and a concentration-dependent manner. The present approach may be combined to enhance the chemosensitivity, improve the dose of cytotoxic drugs and evaluate the effects of novel anticancer drugs.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 132 (6), 777-783, 2012-06-01

    The Pharmaceutical Society of Japan

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