新規人工調製肺サーファクタントの研究と高機能性特化への応用展開

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タイトル別名
  • A Study on Novel Artificial Lung Surfactants Incorporated with Partially Fluorinated Amphiphiles
  • シンキ ジンコウ チョウセイ ハイ サーファクタント ノ ケンキュウ ト コウキノウセイ トッカ エ ノ オウヨウ テンカイ

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  Lung surfactants (LS), a complex of ∼90 wt% lipids (mainly dipalmitoylphosphatidylcholine or DPPC) and ∼10 wt% surfactant proteins (SP-A, -B, -C, and -D), adsorb to an air-alveolar fluid interface and then lower its surface tension down to near zero during expiration. Intratracheal instillation of exogenous LS preparations can effectively compensate for surfactant deficiency in premature infants with respiratory distress syndrome (RDS). Surfacten® (Mitsubishi Tanabe Pharma Corporation, Osaka, Japan), a modified bovine lung extract and an effective surfactant replacement in treatment for RDS patients, is supplemented with DPPC, palmitic acid, and tripalmitin. For the premature infants suffering from RDS, instillation of Surfacten® leads to a dramatic improvement in lung function and compliance. Herein, the author reviews potential use of newly designed preparations containing a mimicking peptide of SP-B and also introduces the current research on the preparations incorporated with partially fluorinated amphiphiles to improve their efficacy.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 132 (7), 817-822, 2012-07-01

    公益社団法人 日本薬学会

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