Convenient TLC-based Identification Test for the Crude Drug “Pogostemoni Herba”

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  • AMAKURA Yoshiaki
    College of Pharmaceutical Sciences, Matsuyama University
  • YOSHIMURA Morio
    College of Pharmaceutical Sciences, Matsuyama University
  • MOURI Chika
    Graduate School of Natural Science and Technology, Kanazawa University
  • MIKAGE Masayuki
    Graduate School of Natural Science and Technology, Kanazawa University
  • KAWAHARA Nobuo
    Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences
  • GODA Yukihiro
    Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences
  • YOSHIDA Takashi
    College of Pharmaceutical Sciences, Matsuyama University

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Description

TLC and HPLC were used to identify possible chemical markers for evaluating the quality of the crude drug “Pogostemoni herba” (aerial part of Pogostemon cablin), which is a component of Kampo medicines. In addition to the reported patchouli alcohol and 2-hydroxy-6-methyl-3-(4-methylpentanoyl)-4-pyrone, three phenylethanoids were isolated from this plant material for the first time: acteoside, isoacteoside, and crenatoside. The usefulness of these compounds as indicators of the crude commercial drug under various TLC conditions was examined, and patchouli alcohol was found to give a definite spot with a reproducible Rf value. Therefore, we propose TLC of the methanol (MeOH) extract using patchouli alcohol as a marker as a convenient method for identifying the crude drug Pogostemoni herba.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 128 (12), 1833-1837, 2008-12-01

    The Pharmaceutical Society of Japan

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