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Effect of Food Thickener on Disintegration and Dissolution of Magnesium Oxide Tablets
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- Tomita Takashi
- Department of Pharmacy, Hospital Bando
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- Goto Hidekazu
- Department of Pharmacy, Hospital Bando
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- Yoshimura Yuya
- Kyowa Chemical Industry Co., Ltd.
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- Tsubouchi Yoshiko
- Kyowa Chemical Industry Co., Ltd.
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- Nakanishi Rie
- Department of Pharmacy, Hospital Bando
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- Kojima Chikako
- Department of Pharmacy, Hospital Bando
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- Yoneshima Mihoko
- Department of Pharmacy, Hospital Bando
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- Yoshida Tadashi
- Department of Internal Medicine, Hospital Bando
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- Tanaka Katsuya
- Department of Psychiatry, Hospital Bando
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- Sumiya Kenji
- Faculty of Pharmacy, Iwaki Meisei University
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- Kohda Yukinao
- Department of Pharmacy, Hospital Bando Faculty of Health Sciences, Tsukuba International University
Bibliographic Information
- Other Title
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- とろみ調整食品が酸化マグネシウム錠の崩壊と溶出に及ぼす影響
- トロミ チョウセイ ショクヒン ガ サンカ マグネシウムジョウ ノ ホウカイ ト ヨウシュツ ニ オヨボス エイキョウ
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Description
It has been reported that magnesium oxide tablets are excreted in a non-disintegrated state in the stool of patients when the tablets are administered after being immersed in a food thickener. Therefore we examined whether immersion in a food thickener affects the pharmacological effect in patients taking magnesium oxide tablets, and whether immersion affects its disintegration and solubility. The mean dosage (1705 mg/d) was higher for patients who took tablets after immersion in a food thickener than for those who took non-immersed tablets (1380 mg/d). The disintegration time and dissolution rate of the immersed tablets were lower than those of non-immersed tablets in vitro. Furthermore, components that constitute the food thickener and differences in composition concentrations differentially affect the disintegration and solubility of magnesium oxide tablets. This suggests that commercially available food thickeners are likely to be associated with changes in the degradation of magnesium oxide tablets, and they therefore should be carefully used in certain clinical situations.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 135 (6), 835-840, 2015-06-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681105024000
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- NII Article ID
- 130005071773
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 026502140
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- PubMed
- 26028419
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed