Formulation of Orodispersible Tablets of Ondansetron HCl: Investigations Using Glycine-Chitosan Mixture as Superdisintegrant

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  • GOEL Honey
    Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University
  • VORA Nishant
    Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University
  • TIWARY Ashok K.
    Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University
  • RANA Vikas
    Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University

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  The objective of this investigation was to prepare orodispersible tablets (ODTs) of ondansetron HCl using a direct compression method. A combination of glycine and chitosan was used as a disintegrating system and these tablets were compared for mechanical strength and disintegration time with those containing superdisintegrants. The Plackett-Burman screening design was used to screen the independent variables [concentration of glycine (X1), concentration of chitosan (X2), concentration of ondansetron HCl (X3) and tablet crushing strength (X4)] which were found to actively influence the dependent variables [disintegration time in the oral cavity (DT), wetting time (WT), and water absorption ratio (WAR)]. Further, a central composite design was used to formulate additional ODTs of ondansetron HCl for estimating response in the extended spherical domain. The regression analysis (performed using Statistica-7.0) of quadratic fit revealed that DT or WT and WAR were 99% and 98% correlated with active factors (X1, X2 or X3), respectively. The data showed that disintegration time of optimized ondansetron HCl ODTs was not significantly different (p<0.05) from ODTs prepared using Croscarmellose sodium or Crospovidone.<br>

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  • 薬学雑誌

    薬学雑誌 129 (5), 513-521, 2009-05-01

    公益社団法人 日本薬学会

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