多形核白血球と共同して腫瘍細胞破壊を誘導する植物レクチンの検索

池並 通裕, 山崎 正利

doi:10.1248/yakushi1947.103.12_1298

多形核白血球と共同して腫瘍細胞破壊を誘導する植物レクチンの検索

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書誌事項

タイトル別名

Plant Lectin-Dependent Polymorphonuclear Leukocyte-Mediated Cytolysis
タケイカクハッケッキュウトキョウドウシテシュヨウサイボウハカイオ

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抄録

Some plant lectins have been reported to agglutinate tumor cells. In addition to this function, we report here that some plant lectins can lyse tumor cells in cooperation with polymorphonuclear leukocytes (PMNs). PMNs lysed MM46, MM48, MH134 and EL-4 tumor cells in the presence of wheat germ agglutinin. MM48, MH134, EL-4 and YAC-1 were lysed by PMNs in cooperation with concanavalin A. Neither lectin lysed normal spleen cells. Peanut lectin induced cytolysis of both YAC-1 and normal cells in coopertion with PMNs. In these lectin-dependent PMN-mediated cytolysis, carbohydrate moiety on cell membranes was recognized by lectin. These results show that PMN can lyse tumor cells in the presence of appropriate mediators and that some lectins can participate in tumor lysis.