Studies on Development of the Ultra-fine Size Reduction Method of Slightly Soluble Medicinal Crystals. III. The Inference of Origin for Ultra-fine Size Reduction of Oxolinic Acid Crystal

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  • 難溶性医薬品結晶の超微細化方法の開発に関する研究(第3報)オキソリン酸結晶の超微細化の成因の推論
  • 難溶性医薬品結晶の超微細化方法の開発に関する研究-3-オキソリン酸結晶の超微細化の成因の推論
  • ナンヨウセイ イヤクヒン ケッショウ ノ チョウ ビサイカ ホウホウ ノ カイ

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Abstract

It was found in the previous papers that oxolinic acid (OA) crystals were reduced to ultra-fine size by the new method of present authors. Therefore, several investigations were carried out to infer the origin for ultra-fine size reduction in this paper. It was inferable from the results that surfactants or polymers which coexisted in the crystal formation-growth process adsorbed on the surface of microparticles, and the size reduction effect had been displayed due to suppressing the aggregation for their dispersing action.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 103 (11), 1215-1218, 1983

    The Pharmaceutical Society of Japan

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