Molecular Understanding of the Acquisition of Resistance to Anti-cancer Drugs Associated with the Exacerbation of Cancer

Kuzumaki Naoko, Narita Michiko, Ikegami Daigo, Narita Minoru

doi:10.1248/yakushi.15-00262-3

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次世代型“包括的がん緩和医療”への取り組み—抗がん剤による耐性獲得及びがん増悪化の分子理解
Symposium Review 次世代型"包括的がん緩和医療"への取り組み : 抗がん剤による耐性獲得及びがん増悪化の分子理解
Symposium Review ジセダイガタ"ホウカツテキガンカンワイリョウ"ヘノトリクミ : コウガンザイニヨルタイセイカクトクオヨビガンゾウアッカノブンシリカイ

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Abstract

Gefitinib and erlotinib target the ATP cleft in the tyrosine kinase EGFR, which is overexpressed in 40-80 percent of non-small-cell lung cancer (NSCLC) and many other epithelial cancers. However, the application of gefitinib is ultimately limited by the emergence of mutations and other molecular mechanisms conferring drug resistance. Furthermore, it has been considered that acquired resistance to gefitinib is associated with a clinically significant risk of accelerated disease progression. We previously established a new gefitinib-resistant NSCLC cell line, HCC827GR, which harbors the T790M mutation. Using HCC827GR, we found that the inhibition of adenosine A2a receptors of NSCLC regulated cancer proliferation and exacerbation, indicating that adenosine A2a receptors may be new targets for a novel strategy in NSCLC therapy. These findings suggest that multilayered crosstalk between G-protein coupled receptors (GPCRs) and EGFR may play an important role in regulating downstream signaling molecules that are implicated in the development of gefitinib-resistant NSCLC.<br>

Journal

YAKUGAKU ZASSHI

YAKUGAKU ZASSHI 136 (5), 699-703, 2016-05-01

The Pharmaceutical Society of Japan

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