抗菌性ペプチドMagainin 2 とTachyplesin I の細菌選択的相乗効果:カクテル療法への可能性
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- 小林 聖枝
- 京都大学大学院薬学研究科
書誌事項
- タイトル別名
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- Bacteria-Selective Synergism between the Antimicrobial Peptides Magainin 2 and Tachyplesin I: Toward Cocktail Therapy
- 抗菌性ペプチドMagainin 2とTachyplesin 1の細菌選択的相乗効果:カクテル療法への可能性
- コウキンセイ ペプチド Magainin 2 ト Tachyplesin 1 ノ サイキン センタクテキ ソウジョウ コウカ カクテル リョウホウ エ ノ カノウセイ
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抄録
Magainin 2 and tachyplesin I (T-SS) are membrane-permeabilizing antimicrobial peptides discovered in frog skin and horseshoe crab hemolymph, respectively. They are classified into different secondary structural classes, i.e., α-helix and cyclic β-sheet, respectively. We found that F5W-magainin 2 (MG2) and T-SS showed marked synergistic effects against gram-negative and -positive bacteria without enhancing hemolytic activity as a measure of toxicity. The results of dye-release experiments using liposomes suggested that the selective synergism is mainly due to anionic phospholipid-specific synergism in membrane permeabilization. Furthermore, the cyclic structure of T-SS was found to be necessary for synergism because a linear analogue of T-SS did not show good synergism with MG2. These novel observations suggest the possibility of development of cocktail therapeutic regimens using combinations of antimicrobial peptides.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 122 (11), 967-973, 2002-11-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105429376
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- NII論文ID
- 10010204314
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD38XovF2htbk%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 6342333
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- PubMed
- 12440153
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可