Preparation and Characterization of (5-Methyl-2-oxo-1,3-dioxol-4-yl) methyl Thiamine Sulfides

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  • （5-Methyl-2-oxo-1,3-dioxol-4-yl) methyl Thiamine Sulfide の合成と性状
  • 5 Methyl 2 oxo 1 3 dioxol 4 yl methyl Thiamine Sulfide ノ ゴウセイ ト セイジョウ

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Description

  A new type of S-protected thiol-type thiamines (prodrugs), which have a (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl group recognized as a biologically safe promoiety, were designed, prepared, and confirmed to show higher serum thiamine levels after oral administration to rats than after that of thiamine itself and bisbentiamin as standards. Thus it was shown that the promoiety should be also used for improvement of poor oral absorption of drugs with a mercapto group, in addition to the absorption of drugs with carboxyl, amino, and hydroxyl groups.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 126 (3), 179-186, 2006-03-01

    The Pharmaceutical Society of Japan

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