A Novel Deprotonative Functionalization of Aromatics with Phosphazene Base
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- IMAHORI Tatsushi
- Graduate School of Pharmaceutical Sciences, Tohoku University
Bibliographic Information
- Other Title
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- フォスファゼン塩基を用いる芳香環化合物の新規脱プロトン—修飾反応
- フォスファゼン塩基を用いる芳香環化合物の新規脱プロトン--修飾反応
- フォスファゼン エンキ オ モチイル ホウコウカン カゴウブツ ノ シンキ ダツプロトン シュウショク ハンノウ
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Description
A novel type of deprotonative functionalization of aromatics was accomplished with a phosphazene base (t-Bu-P4 base). For various nitrogen heteroaromatics and benzene derivatives, deprotonative 1,2-additions proceeded with the t-Bu-P4 base and ZnI2 as an additive in the presence of carbonyl compounds. The t-Bu-P4 base has both extremely strong Brønsted basicity and less nucleophilicity due to its huge, widely conjugated structure, and highly chemoselective deprotonations were achieved. In addition the nonmetallic t-Bu-P4 base should not function as a Lewis acid. Therefore the deprotonation with the t-Bu-P4 base is considered to proceed via a different pathway from traditional deprotonative metalation of aromatics with metallic bases. Some reactions with unique regioselectivities were observed.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 124 (8), 509-517, 2004-08-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681105584512
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- NII Article ID
- 110003614981
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 7046432
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- PubMed
- 15297720
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed